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Tasuku Honjo Born on 27, January 1942. is Distinguished Professor of Kyoto University Institute for Advanced Study and concurrently Professor of Department of Immunology and Genomic Medicine, Kyoto University, and also Chairman of Board of Directors, Foundation for Biomedical Research and Innovation.
He has established the basic conceptual framework of class switch recombination starting from the discovery of DNA deletion (1978) and S regions (1980), followed by elucidation of the whole mouse immunoglobulin heavy-chain locus.
Dr. Tasuku Honjo is well known for his discovery of activation-induced cytidine deaminase that is essential for class switch recombination and somatic hypermutation.
Honjo discovered PD-1 (program cell death 1), a negative coreceptor at the effector phase of immune response and showed that PD-1 modulation contributes to treatments of viral infection, tumor, and autoimmunity.
For these contributions, Dr.Tasuku Honjo has received many awards, including Imperial Prize (1996), Japan Academy Prize (1996), Robert Koch Prize (2012), Order of Culture (2013), the Keio Medical Science Prize (2016) and Japan Bioindustry Award (2017).
Honjo also awarded the Nobel Prize in Physiology or Medicine jointly to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation'' the Nobel Assembly at Karolinska Institute on October 1, 2018.
Nobel Prize in medicine for Cancer Therapy: Cure of cancer w...
James P. Allison, Tasuku Honjo accorded Nobel Prize 2018 in ...